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KMID : 0191120120270050547
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Journal of Korean Medical Science
2012 Volume.27 No. 5 p.547 ~ p.552
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Hepatic Ischemic Preconditioning Provides Protection Against Distant Renal Ischemia and Reperfusion Injury in Mice
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Lee Jung-Ah
Choi Jin-Woo
In Jang-Hyeok
Jung Hong-Soo
Kim Yong-Shin
Jeon Yeon-Soo
Kang Yoo-Jin
Kim Dae-Woo
Lim Yong-Gul
Park Jae-Hee
Joo Jin-Deok
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Abstract
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We previously demonstrated that there are acute and delayed phases of renal protection against renal ischemia and reperfusion (IR) injury with renal ischemic preconditioning (IPC). This study assessed whether hepatic IPC could also reduce distant renal IR injury through the blood stream-mediated supply of reactive oxygen species (ROS). Male C57BL/6 mice were randomly divided into four groups: group I, sham operated including right nephrectomy; group II (IR), left renal ischemia for 30 min and reperfusion injury; group III (IPC-IR), hepatic ischemia for 10 min followed by 10 min of reperfusion before left renal IR injury; group IV (MPG - IPC + IR), pretreated with 100 mg/kg N-(2-mercaptopropionyl)-glycine (MPG) 15 min before hepatic IPC and left renal IR injury. Renal function, histopathologic findings, proinflammatory cytokines, and cytoprotective proteins were evaluated 15 min or 24 hr after reperfusion. Hepatic IPC attenuated the expression of proinflammatory cytokines, tumor necrosis factor α, intercellular adhesion molecule 1, and induced inducible nitric-oxide synthase, and the phosphorylation of Akt in the murine kidney. Renal function was better preserved in mice with hepatic IPC (group III) than groups II or IV. Hepatic IPC protects against distant renal IR injury through the blood stream-delivery of hepatic IPC-induced ROS, by inducing cytoprotective proteins, and by inhibiting inflammatory reactions.
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KEYWORD
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Cytoprotective Proteins, Ischemic Preconditioning (IPC), Ischemia and Reperfusion (IR) Injury, Proinflammatory Cytokines
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